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Prof. Dr. med. Nikolaus Plesnila

Head of Laboratory of Experimental Stroke Research


Institute for Stroke and Dementia Research (ISD), LMU Munich Medical School


Institute for Stroke and Dementia Research (ISD)
Großhadern Max-Lebsche Platz 30
D-81377 Munich

Phone: +49 (89) 4400-7 8357 or 8363
Fax: +49 (89) 4400-7 8369


Research Focus

The Laboratory of Experimental Stroke Research (LaESR) is devoted to uncover the pathophysiology of ischemic and hemorrhagic stroke as the basis for the development of novel therapeutic options for stroke patients. Accordingly, the LaESR will be an integral part of ISD’s translational research strategy.

The main expertise of the laboratory gathers around experimental stroke models (transient & permanent focal cerebral ischemia, global ischemia, subarachnoid hemorrhage) and around methodologies for the investigation of the cerebral microcirculation (intravital microscopy using conventional and 2-photon excitation).

 The thematic focus of Prof. Plesnila’s team is the role of neurovascular dysfunction for the pathophysiology of acute and chronic stroke syndromes. Specifically, the laboratory will work on the pathophysiology of microcirculatory dysfunction (including the blood-brain barrier) and small vessel disease (SVD).

Primary techniques: in vivo models of ischemic and hemorrhagic stroke, in vivo 1- and 2-photon microscopy, histology/immunohistochemistry, microdissection microscopy, behavioural analysis

Model Organism(s): mouse