|Surname, First name
|The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses.
|Stroke is one of the leading causes of death and mortality worldwide. One of the main risk factors for stroke onset is exposure to environmental toxins. Some of these environmental toxins that affect human health include dioxins and polyaromatic hydrocarbons. Both compounds have a high affinity for the aryl hydrocarbon receptor (AhR) which is ubiquitously expressed in immune cells at barrier sites, including the gut, the lung and meninges. For this project, we will test specific environmental toxins, ligands of AhR, and characterize the immune response and microbial composition before and after exposure to the toxin and evaluate the impact on stroke severity in mice.
|Research in Hartl and Hayer-Hartl laboratory focuses on the mechanisms of protein folding and quality control in the cell. Our goal is to reach a comprehensive understanding, at the structural and functional level, of how the machinery of molecular chaperones assists folding through the cooperation of co- and post-translational mechanisms.
|The discovery and functional analysis of the chaperonins was instrumental in shaping our present view of de novo protein folding as a chaperone-assisted process.
|Physiological function of proteins involved in Neurodegenerative diseases, synaptic failure in Neurodegenerative diseases like Alzheimer’s or Parkinson’s disease (AD,PD), long-term in vivo two-photon imaging of transgenic mice models of AD, neuronal calcium homeostasis in neurodegenerative diseases, high-throughput drug screens for AD and PD.
|The amygdala is a cluster of highly conserved nuclei at the base of the brain, important for appetitive and aversive behaviours. We use viral tracing, behaviour, histology and electrophysiology to answer the questions related.
|The research in our group is strongly focused on the plant chloroplasts and transport processes in this organelle. We are particularly interested in ion transport proteins. Currently, we are working on the identification of their substrates and molecular mechanisms. In this context we are interested in organelle development, stress signals and photosynthesis. In our studies we mainly use Arabidopsis thalian as a plant model organism. With growing enthusiasm, however, we are also interested in algae.
|Next summer, join us in investigating the intricate link between glucose metabolism, transcriptional control and gene regulation in eukaryotes. Our project focuses on how the sugar-tolerance transcription factor ChREBP and its paralogs directly sense cellular metabolites to drive large changes in gene activity.
|We study how Alzheimer’s disease develops in the brain on the molecular and cellular level. The aim of our research is to better understand the disease causes and to develop new diagnostic, therapeutic and preventive approaches.
|We have previously established a novel primary microglia culture protocol from mouse retina, which allows for good reproducibility, high cell numbers and long in vitro viability. In order to be able to efficiently manipulate retinal microglia in vivo and in vitro, efficient gene delivery technologies are needed. Within this project, we will evaluate novel-engineered adeno-associated virus (AAV) capsids regarding efficacy and specificity. These AAV variants will be tested in our mouse retinal microglia culture model, mouse retinal explant cultures and in a mouse model of retinal degeneration to validate their efficacy and specificity in vitro, ex vivo and in vivo.
|The Misgeld lab uses in vivo imaging methods (ranging from wide-field time-lapse to two-photon microscopy) to study the development and degeneration of neurons and their processes.
|To promote our understanding of how plants acclimate to a changing environment, our research focuses on the quantitative analysis of metabolic regulation.
|Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport.
|Stricker, Stefan H.
|The research aim of the lab is to investigate how cells know which cell type they are and why they never forget. We employ a wide range of CRISPR methods to brain cells to test in vitro and in vivo, which epigenetic marks and gene activities have functional relevance in mediating cell identity or disease phenotypes.
|The Laboratory for Neurodegenerative Disease Research focuses on the generation of Amyloid ß-peptide (Aß) as the major constituent of neurotoxic amyloid plaques in Alzheimer's Disease (AD).