|Surname, First name
|The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses.
|Becker, Peter B.
|We are interested in how functional states derive from the interplay of opposing principles: those that endow chromatin structures with plasticity and enable a cell to respond to developmental, metabolic and environmental signals, and others, promoting the assembly of lasting, heritable structures that organise chromosomes and define cellular identity.
| Monitoring membrane transport processes with fluroescent chemosensors.
|Based on the findings on EMT in HNSCC, the aims of the project are two-fold. Firstly, we aim to further explore the novel regulatory networks of EGFR in HNSCC and identify gene signature(s) characterizing EGFR-mediated EMT from preclinical to clinical status to improve HNSCC stratification with a special focus on local recurrences, lymph node status, and response to EGFR-specific therapeutic agents. Secondly, we aim to identify prospective therapeutic targets, i.e. genes that make up EGFR-mediated signatures will be further described at the functional, molecular level in adequate cellular models.
|Research in Hartl and Hayer-Hartl laboratory focuses on the mechanisms of protein folding and quality control in the cell. Our goal is to reach a comprehensive understanding, at the structural and functional level, of how the machinery of molecular chaperones assists folding through the cooperation of co- and post-translational mechanisms.
|The discovery and functional analysis of the chaperonins was instrumental in shaping our present view of de novo protein folding as a chaperone-assisted process.
|We study the proteomic composition of distinct chromatin domains, the mechanisms that operate to maintain the composition of histone modifications and the associated proteins at a given DNA locus.
|We study nucleosome positioning mechanisms with unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as in vivo and in vitro model. As our specialty, we established the first genome-wide reconstitution system that allows the biochemical characterization of factors and their roles in nucleosome positioning.
|The research in our group is strongly focused on the plant chloroplasts and transport processes in this organelle. We are particularly interested in ion transport proteins. Currently, we are working on the identification of their substrates and molecular mechanisms. In this context we are interested in organelle development, stress signals and photosynthesis. In our studies we mainly use Arabidopsis thalian as a plant model organism. With growing enthusiasm, however, we are also interested in algae.
|Next summer, join us in investigating the intricate link between glucose metabolism, transcriptional control and gene regulation in eukaryotes. Our project focuses on how the sugar-tolerance transcription factor ChREBP and its paralogs directly sense cellular metabolites to drive large changes in gene activity.
|We study how Alzheimer’s disease develops in the brain on the molecular and cellular level. The aim of our research is to better understand the disease causes and to develop new diagnostic, therapeutic and preventive approaches.
|We have previously established a novel primary microglia culture protocol from mouse retina, which allows for good reproducibility, high cell numbers and long in vitro viability. In order to be able to efficiently manipulate retinal microglia in vivo and in vitro, efficient gene delivery technologies are needed. Within this project, we will evaluate novel-engineered adeno-associated virus (AAV) capsids regarding efficacy and specificity. These AAV variants will be tested in our mouse retinal microglia culture model, mouse retinal explant cultures and in a mouse model of retinal degeneration to validate their efficacy and specificity in vitro, ex vivo and in vivo.
|Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport.
|The Amgen scholar will be involved in designing (cloning) and optimizing (purification) different protein constructs followed by screening LLPS conditions using microscopy and biochemical characterization, ie protein-protein interactions, using nuclear magnetic resonance (NMR) spectroscopy, electron microscopy (EM) and other biophysical techniques (ITC, SLS), which will ultimately provide foundation to obtain a structural model of the peroxisomal protein import machinery.
|Schmidt, Mathias V.
|Project 1: Characterizing long-term outcomes of developmental stress exposure in a translational mouse model / Project 2: Investigation into the Role of FKBP51 in Obesity and Type 2 Diabetes
|The biochemical pathway of chlorophyll degradation has only recently been characterized. The metabolites that are yielded from the breakdown path – the phyllobilins – were shown to have antioxidant properties.