|Surname, First name
|The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses.
|Stroke is one of the leading causes of death and mortality worldwide. One of the main risk factors for stroke onset is exposure to environmental toxins. Some of these environmental toxins that affect human health include dioxins and polyaromatic hydrocarbons. Both compounds have a high affinity for the aryl hydrocarbon receptor (AhR) which is ubiquitously expressed in immune cells at barrier sites, including the gut, the lung and meninges. For this project, we will test specific environmental toxins, ligands of AhR, and characterize the immune response and microbial composition before and after exposure to the toxin and evaluate the impact on stroke severity in mice.
|We investigate the fundamental principles of synaptic plasticity at a number of different levels, ranging from molecular approaches to studies of the intact nervous system.
|In the Institute of Clinical Neurosciences, studies address vestibular function in health and disease from eye movement recordings to perception using various methods such as psychophysical measurements, eye movement recordings, fMRI and computational modeling.
|Project 1: Advanced Imaging of Cancer Metastasis in Whole Mouse Body / Project 2: Whole-body imaging of nanoparticles
|Our overarching goal is to better understand the mechanisms that promote the development and progression of Alzheimer’s disease in order to develop clinically applicable personalized medicine models for predicting patient-specific disease trajectories.
|Our lab is interested in understanding neuronal circuit functions of the insular cortex as part of a wider neuronal network comprising prefrontal and limbic brain structures.
|Physiological function of proteins involved in Neurodegenerative diseases, synaptic failure in Neurodegenerative diseases like Alzheimer’s or Parkinson’s disease (AD,PD), long-term in vivo two-photon imaging of transgenic mice models of AD, neuronal calcium homeostasis in neurodegenerative diseases, high-throughput drug screens for AD and PD.
|Data analysis, computational/mathematical modelling and theoretical investigation of neurobiological mechanisms underlying spatial orientation and navigation. Focus: Single-cell and network behavior of head-direction and grid-cell systems within the rodent entorhinal cortex.
|Determination of mass spectrometric properties of tubulin modified C-terminal peptides
|The amygdala is a cluster of highly conserved nuclei at the base of the brain, important for appetitive and aversive behaviours. We use viral tracing, behaviour, histology and electrophysiology to answer the questions related.
|Our laboratory is interested in how ambient sensory stimulation activates neuromodulators and how these then influence the processing of relevant information.
|Our major research focus is on the correlation of cellular metabolism (energy production and consumption) and electrical activity in neurones.
|We study how Alzheimer’s disease develops in the brain on the molecular and cellular level. The aim of our research is to better understand the disease causes and to develop new diagnostic, therapeutic and preventive approaches.
|We have previously established a novel primary microglia culture protocol from mouse retina, which allows for good reproducibility, high cell numbers and long in vitro viability. In order to be able to efficiently manipulate retinal microglia in vivo and in vitro, efficient gene delivery technologies are needed. Within this project, we will evaluate novel-engineered adeno-associated virus (AAV) capsids regarding efficacy and specificity. These AAV variants will be tested in our mouse retinal microglia culture model, mouse retinal explant cultures and in a mouse model of retinal degeneration to validate their efficacy and specificity in vitro, ex vivo and in vivo.
|The Misgeld lab uses in vivo imaging methods (ranging from wide-field time-lapse to two-photon microscopy) to study the development and degeneration of neurons and their processes.
|Myoga, Michael H.
|We study how spatial information from multiple senses converges in the midbrain of mice. With a focus on how auditory information integrates with its visual counterparts, we employ in vitro patch-clamp electrophysiology, optogenetic-based circuit mapping, and anatomical tracing techniques.
|We focus on basic and translational research in the field of the central nervous system (CNS) repair and regeneration aiming at novel strategies for brain repair and regeneration by modulating the function of glial cells. We aim at providing a basis for the development of new therapies for patients affected by stroke, neurotrauma or neurodegenerative diseases.
|The main interest of the laboratory is to study the role of cerebral vessels for the pathophysiology of acute and chronic brain injury and to use the evolving knowledge for the development of novel therapeutic strategies for patients. For this purpose we use clinically relevant mouse models for acute and chronic brain injury and investigate neuro-vascular morphology and function by in vivo microscopy using conventional and 2-photon fluorescence microscopy.
|On a systems neuroscience level we are working on the brain mechanisms of pain perception. We aim to further the understanding of the brain processes, which determine the individual sensitivity of a person to pain, which explain why we perceive the same painful event differently in different situations.
|My group is interested in how brains process sensory stimuli and use them to select appropriate motor output.
|Schmidt, Mathias V.
|Project 1: Characterizing long-term outcomes of developmental stress exposure in a translational mouse model / Project 2: Investigation into the Role of FKBP51 in Obesity and Type 2 Diabetes
|Our research is focused on the mechanisms of information representation and propagation within and across different cortical networks.
|Stricker, Stefan H.
|The research aim of the lab is to investigate how cells know which cell type they are and why they never forget. We employ a wide range of CRISPR methods to brain cells to test in vitro and in vivo, which epigenetic marks and gene activities have functional relevance in mediating cell identity or disease phenotypes.
|We aim to identify circulating signatures that inform on the local and systemic effects of stroke and to explore the underlying molecular and pathophysiological mechanisms. Events in most organs including the local and systemic events (e.g. stress) related to acute stroke are captured by the circulating proteome and metabolome.
|We perceive visual features such as color, form, or size of objects not in isolation but depending on the visual context. Contextual influences are thought to play an important role in reliable and efficient perception. In this project we will perform quantitative measurements of visual performance and use models of neural processing to investigate the neural mechanisms underlying contextual influences on visual perception.