Amgen Scholars Program

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Surname, First name Research Focus Availability
Hartl, Ulrich Research in Hartl and Hayer-Hartl laboratory focuses on the mechanisms of protein folding and quality control in the cell. Our goal is to reach a comprehensive understanding, at the structural and functional level, of how the machinery of molecular chaperones assists folding through the co­operation of co- and post-translational mechanisms. available
Hayer-Hartl, Manajit The discovery and functional analysis of the chaperonins was instrumental in shaping our present view of de novo protein folding as a chaperone-assisted process. not available
Herms, Jochen Physiological function of proteins involved in Neurodegenerative diseases, synaptic failure in Neurodegenerative diseases like Alzheimer’s or Parkinson’s disease (AD,PD), long-term in vivo two-photon imaging of transgenic mice models of AD, neuronal calcium homeostasis in neurodegenerative diseases, high-throughput drug screens for AD and PD. not available
Imhof, Axel We study the proteomic composition of distinct chromatin domains, the mechanisms that operate to maintain the composition of histone modifications and the associated proteins at a given DNA locus. available
Kielkowski, Pavel Determination of mass spectrometric properties of tubulin modified C-terminal peptides available
Lichtenthaler, Stefan We study how Alzheimer’s disease develops in the brain on the molecular and cellular level. The aim of our research is to better understand the disease causes and to develop new diagnostic, therapeutic and preventive approaches. not available
Nägele, Thomas To promote our understanding of how plants acclimate to a changing environment, our research focuses on the quantitative analysis of metabolic regulation. not available
Niessing, Dierk Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport. not available
Sattler, Michael The Amgen scholar will be involved in designing (cloning) and optimizing (purification) different protein constructs followed by screening LLPS conditions using microscopy and biochemical characterization, ie protein-protein interactions, using nuclear magnetic resonance (NMR) spectroscopy, electron microscopy (EM) and other biophysical techniques (ITC, SLS), which will ultimately provide foundation to obtain a structural model of the peroxisomal protein import machinery. available
Schmidt, Mathias V. Project 1: Characterizing long-term outcomes of developmental stress exposure in a translational mouse model / Project 2: Investigation into the Role of FKBP51 in Obesity and Type 2 Diabetes available
Turck, Christoph W. The comparison of the proteome of diseased and healthy tissues and body fluids and the subsequent identification of the proteins that are different from normal in disease are pursued in order to unravel the pathogenesis of disease, to identify therapeutic targets, and to develop diagnostic tests. not available