|Surname, First name
|The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses.
|Becker, Peter B.
|We are interested in how functional states derive from the interplay of opposing principles: those that endow chromatin structures with plasticity and enable a cell to respond to developmental, metabolic and environmental signals, and others, promoting the assembly of lasting, heritable structures that organise chromosomes and define cellular identity.
|We study nucleosome positioning mechanisms with unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as in vivo and in vitro model. As our specialty, we established the first genome-wide reconstitution system that allows the biochemical characterization of factors and their roles in nucleosome positioning.
|Next summer, join us in investigating the intricate link between glucose metabolism, transcriptional control and gene regulation in eukaryotes. Our project focuses on how the sugar-tolerance transcription factor ChREBP and its paralogs directly sense cellular metabolites to drive large changes in gene activity.
|We have previously established a novel primary microglia culture protocol from mouse retina, which allows for good reproducibility, high cell numbers and long in vitro viability. In order to be able to efficiently manipulate retinal microglia in vivo and in vitro, efficient gene delivery technologies are needed. Within this project, we will evaluate novel-engineered adeno-associated virus (AAV) capsids regarding efficacy and specificity. These AAV variants will be tested in our mouse retinal microglia culture model, mouse retinal explant cultures and in a mouse model of retinal degeneration to validate their efficacy and specificity in vitro, ex vivo and in vivo.
|Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport.
|The Amgen scholar will be involved in designing (cloning) and optimizing (purification) different protein constructs followed by screening LLPS conditions using microscopy and biochemical characterization, ie protein-protein interactions, using nuclear magnetic resonance (NMR) spectroscopy, electron microscopy (EM) and other biophysical techniques (ITC, SLS), which will ultimately provide foundation to obtain a structural model of the peroxisomal protein import machinery.
|Schmidt, Mathias V.
|Project 1: Characterizing long-term outcomes of developmental stress exposure in a translational mouse model / Project 2: Investigation into the Role of FKBP51 in Obesity and Type 2 Diabetes
|Stricker, Stefan H.
|The research aim of the lab is to investigate how cells know which cell type they are and why they never forget. We employ a wide range of CRISPR methods to brain cells to test in vitro and in vivo, which epigenetic marks and gene activities have functional relevance in mediating cell identity or disease phenotypes.
|Novel molecular therapeutics like siRNA, microRNAs or antagomiRs require potent extracellular and intracellular delivery devices to be effective antitumor agents.