| Alcami, Pepe |
My research aims at understanding how cells communicate with each other in the brain, how this communication underlies computations and coding in neural networks and how it ultimately determines behavior. |
TBA |
| Baier, Herwig |
The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses. |
TBA |
| Benakis, Corinne |
Stroke is one of the leading causes of death and mortality worldwide. One of the main risk factors for stroke onset is exposure to environmental toxins. Some of these environmental toxins that affect human health include dioxins and polyaromatic hydrocarbons. Both compounds have a high affinity for the aryl hydrocarbon receptor (AhR) which is ubiquitously expressed in immune cells at barrier sites, including the gut, the lung and meninges. For this project, we will test specific environmental toxins, ligands of AhR, and characterize the immune response and microbial composition before and after exposure to the toxin and evaluate the impact on stroke severity in mice. |
TBA |
| Bonhoeffer, Tobias |
We investigate the fundamental principles of synaptic plasticity at a number of different levels, ranging from molecular approaches to studies of the intact nervous system. |
TBA |
| Brandt, Thomas |
In the Institute of Clinical Neurosciences, studies address vestibular function in health and disease from eye movement recordings to perception using various methods such as psychophysical measurements, eye movement recordings, fMRI and computational modeling. |
TBA |
| Ertürk, Ali |
Project 1: Advanced Imaging of Cancer Metastasis in Whole Mouse Body / Project 2: Whole-body imaging of nanoparticles |
TBA |
| Franzmeier, Nicolai |
Cerebral amyloid angiopathy (CAA) is highly prevalent in the elderly and occurs in up to 80% of patients with Alzheimer’s disease. CAA is characterized by the accumulation of amyloid-beta in the vessel walls, which leads to vessel dysfunction and often results in hemorrhagic stroke. This project seeks to understand the factors contributing to the progression of brain injury in CAA. |
available |
| Gires, Olivier |
Based on the findings on EMT in HNSCC, the aims of the project are two-fold. Firstly, we aim to further explore the novel regulatory networks of EGFR in HNSCC and identify gene signature(s) characterizing EGFR-mediated EMT from preclinical to clinical status to improve HNSCC stratification with a special focus on local recurrences, lymph node status, and response to EGFR-specific therapeutic agents. Secondly, we aim to identify prospective therapeutic targets, i.e. genes that make up EGFR-mediated signatures will be further described at the functional, molecular level in adequate cellular models. |
available |
| Gogolla, Nadine |
Our lab is interested in understanding neuronal circuit functions of the insular cortex as part of a wider neuronal network comprising prefrontal and limbic brain structures. |
TBA |
| Grothe, Benedikt |
We are interested in the neuronal mechanisms of temporal auditory processing and their evolution in mammals. In particular, our studies are concerned with the role of neural inhibition in temporal processing. |
TBA
|
| Hartl, Ulrich |
Research in Hartl and Hayer-Hartl laboratory focuses on the mechanisms of protein folding and quality control in the cell. Our goal is to reach a comprehensive understanding, at the structural and functional level, of how the machinery of molecular chaperones assists folding through the cooperation of co- and post-translational mechanisms. |
not available |
| Hayer-Hartl, Manajit |
The discovery and functional analysis of the chaperonins was instrumental in shaping our present view of de novo protein folding as a chaperone-assisted process. |
not available |
| Hemmert, Werner |
We focus our research on the auditory system where we combine modelling studies with experiments to develop novel approaches for the advancement of neuroprosthetics. |
TBA |
| Herms, Jochen |
Physiological function of proteins involved in Neurodegenerative diseases, synaptic failure in Neurodegenerative diseases like Alzheimer’s or Parkinson’s disease (AD,PD), long-term in vivo two-photon imaging of transgenic mice models of AD, neuronal calcium homeostasis in neurodegenerative diseases, high-throughput drug screens for AD and PD. |
TBA |
| Herz, Andreas |
Data analysis, computational/mathematical modelling and theoretical investigation of neurobiological mechanisms underlying spatial orientation and navigation. Focus: Single-cell and network behavior of head-direction and grid-cell systems within the rodent entorhinal cortex. |
available |
| Imhof, Axel |
We aim to leverage the unique features of Drosophila somatic pairing to gain broader insights into chromosome pairing mechanisms across the tree-of life by investigating chromosme pairing in vitro and analysing the genome and proteome of paired chromosomes. |
available |
| Jung, Kirsten |
Chemotactic behaviour of a motile commensal bacterium |
available |
| Keays, David |
The Keays laboratory is interested in the molecules, cells and circuits that allow animals to detect magnetic fields. This project will explore the molecular architecture of a neuronal circuit that encodes magnetic information within the pigeon brain. |
available |
| Kielkowski, Pavel |
Project 1: Discovering the connection between tyrosination and other microtubule modifications using chemoproteomics / Project 2: Functional characterization of AMPylation on beta-hexosamidase subunit beta (HEXB)
|
available |
| Klein, Rüdiger |
Exploring the Neural Circuitry of Appetite Regulation: The Role of the Central Amygdala (CeA) and Parasubthalamic Nucleus (PSTN) |
available |
| Kopp-Scheinpflug, Conny |
Our laboratory is interested in how ambient sensory stimulation activates neuromodulators and how these then influence the processing of relevant information. |
TBA |
| Korber, Philipp |
We study nucleosome positioning mechanisms with unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as in vivo and in vitro model. As our specialty, we established the first genome-wide reconstitution system that allows the biochemical characterization of factors and their roles in nucleosome positioning. |
not available |
| Kunz, Hans-Henning |
Analysis of putative cyanobacterial thylakoid ion transport proteins for their role in photosynthesis |
available |
| Kunz, Lars |
Our major research focus is on the correlation of cellular metabolism (energy production and consumption) and electrical activity in neurones. |
not available |
| Ladurner, Andreas |
Next summer, join us in investigating the intricate link between glucose metabolism, transcriptional control and gene regulation in eukaryotes. Our project focuses on how the sugar-tolerance transcription factor ChREBP and its paralogs directly sense cellular metabolites to drive large changes in gene activity. |
not available |
| Lichtenthaler, Stefan |
We study how Alzheimer’s disease develops in the brain on the molecular and cellular level. The aim of our research is to better understand the disease causes and to develop new diagnostic, therapeutic and preventive approaches. |
TBA |
| Michalakis, Stylianos |
Engineered adeno-associated virus-based vectors for retinal gene therapy - Mechanistic studies on cellular infection, trafficking and transduction |
available |
| Misgeld, Thomas |
The Misgeld lab uses in vivo imaging methods (ranging from wide-field time-lapse to two-photon microscopy) to study the development and degeneration of neurons and their processes. |
TBA |
| Myoga, Michael H. |
We study how spatial information from multiple senses converges in the midbrain of mice. With a focus on how auditory information integrates with its visual counterparts, we employ in vitro patch-clamp electrophysiology, optogenetic-based circuit mapping, and anatomical tracing techniques. |
not available |
| Nägele, Thomas |
To promote our understanding of how plants acclimate to a changing environment, our research focuses on the quantitative analysis of metabolic regulation. |
not available |
| Niessing, Dierk |
Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport. |
TBA |
| Ninkovic, Jovica |
We focus on basic and translational research in the field of the central nervous system (CNS) repair and regeneration aiming at novel strategies for brain repair and regeneration by modulating the function of glial cells. We aim at providing a basis for the development of new therapies for patients affected by stroke, neurotrauma or neurodegenerative diseases. |
TBA |
| Plesnila, Nikolaus |
Single-Cell Transcriptomics of Stroke and Nitric Oxide Treatment: Investigating Microglia and Neuronal Responses in Mice |
available |
| Ploner, Markus |
On a systems neuroscience level we are working on the brain mechanisms of pain perception. We aim to further the understanding of the brain processes, which determine the individual sensitivity of a person to pain, which explain why we perceive the same painful event differently in different situations. |
TBA |
| Portugues, Ruben |
My group is interested in how brains process sensory stimuli and use them to select appropriate motor output. |
TBA |
| Robles, Maria |
While the circadian clock regulates metabolism, metabolic states, in turn, provide feedback to the circadian clock, modulating its function. We are investigating this molecular crosstalk in peripheral metabolic tissues from mice, employing interaction and spatial proteomics as well as phosphoproteomics. |
available |
| Sattler, Michael |
The Amgen scholar will be involved in designing (cloning) and optimizing (purification) different protein constructs followed by screening LLPS conditions using microscopy and biochemical characterization, ie protein-protein interactions, using nuclear magnetic resonance (NMR) spectroscopy, electron microscopy (EM) and other biophysical techniques (ITC, SLS), which will ultimately provide foundation to obtain a structural model of the peroxisomal protein import machinery. |
TBA |
| Schmidt, Mathias V. |
Deep phenotyping of stress-induced behavioral dynamics |
available |
| Sirota, Anton |
Our research is focused on the mechanisms of information representation and propagation within and across different cortical networks. |
TBA |
| Stricker, Stefan H. |
The research aim of the lab is to investigate how cells know which cell type they are and why they never forget. We employ a wide range of CRISPR methods to brain cells to test in vitro and in vivo, which epigenetic marks and gene activities have functional relevance in mediating cell identity or disease phenotypes. |
TBA |
| Tiedt, Steffen |
We aim to identify circulating signatures that inform on the local and systemic effects of stroke and to explore the underlying molecular and pathophysiological mechanisms. Events in most organs including the local and systemic events (e.g. stress) related to acute stroke are captured by the circulating proteome and metabolome. |
not available |
| Turck, Christoph W. |
The comparison of the proteome of diseased and healthy tissues and body fluids and the subsequent identification of the proteins that are different from normal in disease are pursued in order to unravel the pathogenesis of disease, to identify therapeutic targets, and to develop diagnostic tests. |
not available |
| Vollmar, Angelika |
The biochemical pathway of chlorophyll degradation has only recently been characterized. The metabolites that are yielded from the breakdown path – the phyllobilins – were shown to have antioxidant properties. |
TBA |
| Wachtler, Thomas |
We perceive visual features such as color, form, or size of objects not in isolation but depending on the visual context. Contextual influences are thought to play an important role in reliable and efficient perception. In this project we will perform quantitative measurements of visual performance and use models of neural processing to investigate the neural mechanisms underlying contextual influences on visual perception. |
TBA |
| Wagner, Ernst |
Novel molecular therapeutics like siRNA, microRNAs or antagomiRs require potent extracellular and intracellular delivery devices to be effective antitumor agents. |
TBA |
| Willem, Michael |
The Laboratory for Neurodegenerative Disease Research focuses on the generation of Amyloid ß-peptide (Aß) as the major constituent of neurotoxic amyloid plaques in Alzheimer's Disease (AD). |
not available |
