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PD Dr. Mathias V. Schmidt

Head of the Research Group Neurobiology of Stress Resilience


MPI of Psychiatry, Neurobiology of Stress


Max-Planck-Institute of Psychiatry
Neurobiology of Stress
Kraepelinstr. 2
D-80804 Munich

Phone: +49 (89) 30622 - 519
Fax: +49 (89) 30622 - 610


Research Focus

Stress-associated diseases, with depression leading the way, affect the quality of life of more than a billion people world-wide. It is today undisputed that environmental factors as acute traumatic experiences or chronic stress contribute significantly to the development of depression. On the other hand, it is still largely unknown how specific genetic variants or environmental factor impact on the vulnerability or resilience of an individual to environmental challenges.

The main focus of this research group is to study the impact of acute and chronic stress during different developmental stages in various mouse models. Specifically we are interested in the behavioral, neuroendocrine and molecular basis of individual stress vulnerability and resilience.

To this end we use a broad spectrum of approaches, ranging from different acute or chronic stress models to transgenic or knockout animals. By combining behavioral, neuroendocrine and molecular readouts, we aim to develop novel pharmacological or genetic approaches to modulate, reverse or even prevent individual stress vulnerability.

Primary Technique(s): mouse behavior (anxiety, depression, cognition, etc.), pharmacology, neuroendocrine analysis (RIA), mRNA quantification (in-situ hybridization, qPCR), protein quantification (western blot, immunohistochemistry), stereotactic surgery for the application of viral vectors or pharmacological compounds, structural analysis using high resolution confocal microscopy

Model Organism(s): mice