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Prof. Dr. Angelika Vollmar

Chair of Pharmaceutical Biology, Research Group Dr. Simone Moser

Affiliation

Department of Pharmacy - Center for Drug Research

Contact

Ludwig Maximilians University Munich
Department of Pharmacy - Center for Drug Research
Pharmaceutical Biology
Research Group Dr. Simone Moser
Butenandtstr. 5-13
D-81377 Munich

Phone: +49 (89) 2180 - 77172
Fax: +49 (89) 2180 - 77170

Website: http://www.pharmbiol.cup.uni-muenchen.de/index.html
Website: Research Group Dr. Simone Moser

Research Focus

Part of the Vollmar lab, the Moser research group focuses on a family of plant metabolites, the phyllobilins, which result from the degradation of chlorophyll. The degradation of the green plant pigment is a phenomenon that results in the beautiful colors observed in autumn and is also visible during fruit ripening. The biochemical pathway of chlorophyll degradation has only recently been characterized. The metabolites that are yielded from the breakdown path – the phyllobilins – represent a surprisingly little explored class of natural products despite the facts that they are ubiquitous in nature and part of human nutrition. Exploratory studies have pointed towards interesting properties of phyllobilins, e.g. they were shown to have antioxidant properties.

Phyllobilins occur in a large structural variety in nature, depending on the plant species. The aim of the project is the isolation of phyllobilins from plant sources, as well as the identification of novel phyllobilin structures. We use several chromatographic techniques for the isolation and purification of the metabolites from leaves and fruit, and apply spectroscopic techniques such as MS and NMR for structure elucidation.

Primary techniques: 

Column chromatography, solid phase extraction, HPLC, LC-MS, MS, NMR