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Prof. Dr. Ulrich Hartl

Head of the Department of Cellular Biochemistry

Affiliation

MPI of Biochemistry, Cellular Biochemistry

Contact

Max-Planck-Institute of Biochemistry
Department of Cellular Biochemistry
Am Klopferspitz 18
D-82152 Martinsried

Phone: +49 (89) 8578 - 2244
Fax: +49 (89) 8578 - 2211

Website: http://www.biochem.mpg.de/en/rd/hartl

Research Focus

Protein folding is required for the realization of genetic information at the level of functional proteins and as such is one of the most fundamental reactions in all of biology. Prof. Hartl's group investigates the mechanisms of protein folding in the cell and the consequences of protein misfolding and aggregation in neurodegenerative diseases. Using a broad range of methods from biophysics to cell biology, the goal is to decipher the rules by which the thousands of different proteins in the cytosol utilize the chaperone machinery for de novo folding and assembly. A second major focus is to understand the mechanisms by which protein aggregates cause cytotoxicity and cell death.

Primary Technique(s): Quantitative proteomics, X-ray crystallography, single molecule fluorescence, genetic screening in yeast and mammalian cells

Model Organisms: Escherichia coliSaccharomyces cerevisiae, mammalian cell culture, C. elegans