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Stefan H. Stricker

Dr. Stefan H. Stricker

Group Leader

Affiliation

MCN Junior Research Group & Group Epigenetic Engineering

Contact

Epigenetic Engineering, Institute of Stem Cell Research
Helmholtz Zentrum, German Research Center for Environmental Health

MCN Junior Research Group, Munich Center for Neurosciences
LMU Munich, BioMedical Center
Grosshaderner Strasse 9
Planegg-Martinsried
D-82152

Phone: +49-(0)89-2180-71904

Website: https://www.helmholtz-muenchen.de/isf/research/groups/epigenetic-engineering/research-area/index.html

Research Focus

The research aim of the lab is to investigate which of the myriad of epigenomic marks have significant functional relevance in mediating cell identity or disease phenotypes.

  • Which epigenetic mechanisms trigger these phenotypes?
  • Where are causal epigenomic marks located and how do they work?

Primary techniques and models: To address these questions we use CRISPR/dCas9 fusion proteins to manipulate epigenomic features and/or gene expression. For this we develop, modify and use the following tools and models:

  • Cellular reprogramming, differentiation and trans-differentiation
  • Epigenome and transcriptome editing
  • gRNA multiplexing, libraries and epigenomic screens

stricker topic 625

Image: Schematic of dCas9-based epigenome editing approaches. Taken from “Entering the post-epigenomic age: back to epigenetics.” By Bultmann S, Stricker SH. Open Biol. 2018 Mar;8(3). pii: 180013. doi: 10.1098/rsob.180013. PMID: 29593118

More information can be found in our previous publications:

  • Stricker et al., 2017 Nature reviews genetics
  • Koferle et al., 2017 BMC Genomics
  • reunig et al., 2018 Plos ONE

Model Organism: mouse/human stem cells