MPI of Biochemistry, Cellular Biochemistry
Protein folding is required for the realization of genetic information at the level of functional proteins and as such is one of the most fundamental reactions in all of biology. Prof. Hartl's group investigates the mechanisms of protein folding in the cell and the consequences of protein misfolding and aggregation in neurodegenerative diseases. Using a broad range of methods from biophysics to cell biology, the goal is to decipher the rules by which the thousands of different proteins in the cytosol utilize the chaperone machinery for folding and assembly. A second major focus is to understand the mechanisms by which protein aggregates cause cytotoxicity and cell death.
Primary Technique(s): Quantitative proteomics, X-ray crystallography, single molecule fluorescence, genetic screening in yeast and mammalian cells
Model Organisms: , , mammalian cell culture,